During Backblaze installation it will scan your drive for content to backup and will start backing up anything smaller than 4GB. It will also automatically exclude your system files, as well as virtual machines and disk images. After installation you can excluded folders from the backup.

It’s got a lot more features too. You can change the backup schedule to once a day or manual, get a warning when there was no backup for a number of days, encrypt your files by entering your private encryption key, throttle the backup speed to keep your connection workable.
It also got a nice report showing you how much of each data type (Documents, Music, etc) is selected to backup and even a event log. Interesting it that I am using Dropbox to synchronize content between multiple computers, and it automatically backs that up too.
When you need to restore you can download your files as a zip file for free, or get a DVD (up to 4,7GB, $99) or a USB drive (up to 400GB, $189) sent to you through postal mail for a charge. The cost of all of this? Maximum $5 a month for a monthly recurring payment scheme, and as low as $95 for a two year commitment.
Wanna to try? You can too, as it has a 15 day unlimited data volume trial. And when you uninstall it, all your files will automatically be removed from the datacenter. Eh, what? So if your laptops get stolen and de thief uninstalls Backblaze I loose all my data? Yep. I guess that’s a glitch they need to fix, urgently.
This sounds like something I’ve been looking for, for a very long time. There are other solutions for this kind of thing but I like that you can restore via DVD (or USB) at any point if need be.
For awhile I was tempted to use Mozy, but I might give this a shot.